羧酸的生物催化氢化。
A biocatalytic hydrogenation of carboxylic acids.
机构信息
Delft University of Technology, Department of Biotechnology, Julianalaan 136, 2628BL Delft, The Netherlands.
出版信息
Chem Commun (Camb). 2012 Dec 25;48(99):12056-8. doi: 10.1039/c2cc36479d. Epub 2012 Nov 9.
PMID:23139934
Abstract
The hyperthermophile Pyrococcus furiosus catalyses the hydrogenation of a broad range of carboxylic acids selectively to the corresponding primary alcohols. Other functional groups such as isolated C=C-double bonds are not touched. The chemoselectivity of the carboxylate reduction may be directed towards aldehydes by simple medium engineering.
摘要
嗜热菌 Pyrococcus furiosus 能够选择性地将广泛的羧酸氢化生成相应的伯醇。其他官能团，如孤立的 C=C 双键则不会被触及。通过简单的介质工程，可以将羧酸还原的化学选择性引导至醛。
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