Department of Dermatology, University of Wisconsin-Madison, 1300 University Avenue, 4385 Medical Sciences Center, Madison, WI 53706, USA.
Curr Drug Targets. 2012 Dec;13(14):1831-41. doi: 10.2174/138945012804545489.
Nontoxic naturally occurring compounds, especially those from dietary sources, are receiving increasing consideration for prevention and treatment of diseases including cancer. There is a growing need for innovative anticancer therapies and therefore search for natural compounds with novel biological activities or antineoplastic potential is currently an important area in drug discovery. Support for this interest also comes from increasing concern over the efficacy and safety of many conventional therapies, especially those that run over a long course of time. Laboratory studies in different in vitro and in vivo systems have shown that many natural compounds possess the capacity to regulate response to oxidative stress and DNA damage, suppress angiogenesis, inhibit cell proliferation and induce autophagy and apoptosis. This review discusses the induction of apoptosis and autophagy as a mechanism of cancer prevention by some of the most studied naturally occurring dietary compounds.
非毒性天然存在的化合物，特别是来自饮食来源的化合物，因其在预防和治疗癌症等疾病方面的作用而受到越来越多的关注。人们对创新的抗癌疗法的需求不断增长，因此，寻找具有新型生物活性或抗肿瘤潜力的天然化合物是目前药物发现的一个重要领域。这种兴趣的增加也源于对许多传统疗法的疗效和安全性的担忧，尤其是那些需要长期治疗的疗法。不同体外和体内系统的实验室研究表明，许多天然化合物具有调节对氧化应激和 DNA 损伤的反应、抑制血管生成、抑制细胞增殖以及诱导自噬和细胞凋亡的能力。本文讨论了一些研究最多的天然饮食化合物通过诱导细胞凋亡和自噬来预防癌症的机制。
