诱导细胞凋亡和自噬作为天然存在的膳食因子预防癌症的机制。
Apoptosis and autophagy induction as mechanism of cancer prevention by naturally occurring dietary agents.
机构信息
Department of Dermatology, University of Wisconsin-Madison, 1300 University Avenue, 4385 Medical Sciences Center, Madison, WI 53706, USA.
出版信息
Curr Drug Targets. 2012 Dec;13(14):1831-41. doi: 10.2174/138945012804545489.
Abstract
Nontoxic naturally occurring compounds, especially those from dietary sources, are receiving increasing consideration for prevention and treatment of diseases including cancer. There is a growing need for innovative anticancer therapies and therefore search for natural compounds with novel biological activities or antineoplastic potential is currently an important area in drug discovery. Support for this interest also comes from increasing concern over the efficacy and safety of many conventional therapies, especially those that run over a long course of time. Laboratory studies in different in vitro and in vivo systems have shown that many natural compounds possess the capacity to regulate response to oxidative stress and DNA damage, suppress angiogenesis, inhibit cell proliferation and induce autophagy and apoptosis. This review discusses the induction of apoptosis and autophagy as a mechanism of cancer prevention by some of the most studied naturally occurring dietary compounds.
摘要
非毒性天然存在的化合物，特别是来自饮食来源的化合物，因其在预防和治疗癌症等疾病方面的作用而受到越来越多的关注。人们对创新的抗癌疗法的需求不断增长，因此，寻找具有新型生物活性或抗肿瘤潜力的天然化合物是目前药物发现的一个重要领域。这种兴趣的增加也源于对许多传统疗法的疗效和安全性的担忧，尤其是那些需要长期治疗的疗法。不同体外和体内系统的实验室研究表明，许多天然化合物具有调节对氧化应激和 DNA 损伤的反应、抑制血管生成、抑制细胞增殖以及诱导自噬和细胞凋亡的能力。本文讨论了一些研究最多的天然饮食化合物通过诱导细胞凋亡和自噬来预防癌症的机制。
相似文献
1
Apoptosis and autophagy induction as mechanism of cancer prevention by naturally occurring dietary agents.诱导细胞凋亡和自噬作为天然存在的膳食因子预防癌症的机制。
Curr Drug Targets. 2012 Dec;13(14):1831-41. doi: 10.2174/138945012804545489.
2
Natural products: promising resources for cancer drug discovery.天然产物：癌症药物发现的有前途的资源。
Anticancer Agents Med Chem. 2012 Jan;12(1):49-75. doi: 10.2174/187152012798764697.
3
Plant natural products: from traditional compounds to new emerging drugs in cancer therapy.植物天然产物：从传统化合物到癌症治疗中的新兴药物
Cell Prolif. 2014 Dec;47(6):506-15. doi: 10.1111/cpr.12143.
4
Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy.草药中的天然化合物可能作为自噬诱导剂用于癌症治疗。
Int J Mol Sci. 2017 Jul 1;18(7):1412. doi: 10.3390/ijms18071412.
5
Anti-Cancer Natural Products Inducing Cross-talk between Apoptosis and Autophagy Mutual Proteins to Regulate Cancer Cell Death: Design of Future Green Anticancer Therapies.诱导凋亡与自噬相互蛋白间串扰以调控癌细胞死亡的抗癌天然产物：未来绿色抗癌疗法的设计
Asian Pac J Cancer Prev. 2015;16(14):6175-6. doi: 10.7314/apjcp.2015.16.14.6175.
6
The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy.最具潜力的植物源天然产物在癌症治疗中的靶向凋亡作用
Biomolecules. 2021 Apr 3;11(4):534. doi: 10.3390/biom11040534.
7
Natural Bioactive Compounds, Vegetal Extracts and Modern Pharmaceutical Formulations: New Insights into the Anti-Cancer Mechanism of Action.天然生物活性化合物、植物提取物与现代药物制剂：抗癌作用机制的新见解
Anticancer Agents Med Chem. 2020;20(15):1754-1755. doi: 10.2174/187152062015200911152012.
8
Cancer chemoprevention by natural carotenoids as an efficient strategy.天然类胡萝卜素的癌症化学预防作为一种有效策略。
Anticancer Agents Med Chem. 2015;15(8):1026-31. doi: 10.2174/1871520615666150302125707.
9
Regulation of cell death and survival by resveratrol: implications for cancer therapy.白藜芦醇对细胞死亡和存活的调节：对癌症治疗的启示。
Anticancer Agents Med Chem. 2012 Oct 1;12(8):874-9. doi: 10.2174/187152012802650129.
10
The Application of Embelin for Cancer Prevention and Therapy.恩贝林在癌症预防和治疗中的应用。
Molecules. 2018 Mar 9;23(3):621. doi: 10.3390/molecules23030621.
引用本文的文献
1
Cellular and Molecular Mechanisms Modulated by Genistein in Cancer.染料木黄酮在癌症中调节的细胞和分子机制。
Int J Mol Sci. 2025 Jan 27;26(3):1114. doi: 10.3390/ijms26031114.
2
Anticancer Mechanism of Polysaccharide and Its Application in Cancer Immunotherapy.多糖的抗癌机制及其在癌症免疫治疗中的应用
Pharmaceuticals (Basel). 2024 May 15;17(5):636. doi: 10.3390/ph17050636.
3
Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation.岩藻黄质通过细胞周期阻滞、细胞凋亡诱导、血管生成抑制和自噬调节发挥抗癌作用。
Int J Mol Sci. 2022 Dec 17;23(24):16091. doi: 10.3390/ijms232416091.
4
Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.果胶：一种具有防癌潜力的生物活性食品多糖。
Molecules. 2022 Oct 31;27(21):7405. doi: 10.3390/molecules27217405.
5
Insight into OroxylinA-7--β-d-Glucuronide-Enriched Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment.解析胡黄连苷 A-7-β-D-葡萄糖醛酸苷富集树皮提取物诱导口腔癌细胞 HSC-3 凋亡的机制：线粒体微环境的作用。
Molecules. 2021 Dec 7;26(24):7430. doi: 10.3390/molecules26247430.
6
Effect of and Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines.及提取物对人结肠和前列腺癌细胞系抑制作用的影响。
Curr Issues Mol Biol. 2021 Oct 10;43(3):1518-1528. doi: 10.3390/cimb43030107.
7
Targeting Drug Chemo-Resistance in Cancer Using Natural Products.利用天然产物靶向治疗癌症的化疗耐药性。
Biomedicines. 2021 Sep 29;9(10):1353. doi: 10.3390/biomedicines9101353.
8
Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR-22-3p.桦木酸对lncRNA MALAT1的抑制作用通过miR-22-3p靶向凋亡抑制蛋白来抑制肝细胞癌进展。
Clin Transl Med. 2020 Oct;10(6):e190. doi: 10.1002/ctm2.190.
9
Triggering of Apoptosis in Osteosarcoma 143B Cell Line by Carbon Quantum Dots via the Mitochondrial Apoptotic Signal Pathway.碳量子点通过线粒体凋亡信号通路诱导骨肉瘤 143B 细胞凋亡。
Biomed Res Int. 2020 Jul 10;2020:2846297. doi: 10.1155/2020/2846297. eCollection 2020.
10
The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrol.姜黄素和白藜芦醇对膀胱癌多药耐药性的调控研究
Oncol Lett. 2019 Dec;18(6):6869-6876. doi: 10.3892/ol.2019.11023. Epub 2019 Oct 30.
本文引用的文献
1
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.HO-3867，一种 STAT3 抑制剂，通过失活 BRCA1 突变型卵巢癌细胞中的 STAT3 活性诱导细胞凋亡。
Cancer Biol Ther. 2012 Jul;13(9):766-75. doi: 10.4161/cbt.20559.
2
Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells.没食子醇和姜黄素对胰腺癌细胞增殖抑制和凋亡诱导的协同作用。
J Oncol. 2012;2012:709739. doi: 10.1155/2012/709739. Epub 2012 May 23.
3
Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells.白藜芦醇诱导膀胱癌细胞凋亡与线粒体功能障碍有关。
Int J Urol. 2012 Aug;19(8):757-64. doi: 10.1111/j.1442-2042.2012.03024.x. Epub 2012 May 21.
4
Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases.绿茶多酚通过抑制 class I 组蛋白去乙酰化酶增加 p53 的转录活性和乙酰化。
Int J Oncol. 2012 Jul;41(1):353-61. doi: 10.3892/ijo.2012.1449. Epub 2012 Apr 26.
5
Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells.芹菜素通过外源性途径诱导细胞凋亡，在 HER2 过表达的乳腺癌细胞中诱导 p53 并抑制 STAT3 和 NFκB 信号通路。
Mol Cell Biochem. 2012 Jul;366(1-2):319-34. doi: 10.1007/s11010-012-1310-2. Epub 2012 Apr 20.
6
Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts.诱导线粒体途径和内质网应激以增加异位和原位神经母细胞瘤异种移植中的细胞凋亡
J Cancer Ther. 2011 Jun;2(2):77-90. doi: 10.4236/jct.2011.22009.
7
Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest.白藜芦醇通过细胞周期阻滞使乳腺癌细胞对美法仑增敏。
J Cell Biochem. 2012 Aug;113(8):2586-96. doi: 10.1002/jcb.24134.
8
Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.藤黄酚抑制体内外血管生成的多种特性——对血管预防的意义。
Carcinogenesis. 2012 Feb;33(2):385-93. doi: 10.1093/carcin/bgr282. Epub 2011 Dec 1.
9
Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases.绿茶多酚通过抑制 I 类组蛋白去乙酰化酶引起前列腺癌细胞的细胞周期停滞和凋亡。
Carcinogenesis. 2012 Feb;33(2):377-84. doi: 10.1093/carcin/bgr277. Epub 2011 Nov 23.
10
Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.膳食类黄酮非瑟酮通过诱导 caspase-7 相关凋亡和抑制自噬靶向 caspase-3 缺陷型人乳腺癌 MCF-7 细胞。
Int J Oncol. 2012 Feb;40(2):469-78. doi: 10.3892/ijo.2011.1203. Epub 2011 Sep 15.
Zotero 插件