Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.
Curr Drug Targets. 2012 Dec;13(14):1869-75. doi: 10.2174/138945012804545650.
Ovarian cancer is the leading gynecologic malignancy with more than 22,000 new cases and 15,000 deaths estimated each year. It is usually detected in late stages with poor prognosis due to lack of sufficiently accurate screening tests. Epidemiological studies continue to support the notion that consumption of cruciferous vegetables reduces the risk of ovarian cancer. In the present review article, we describe the anti-cancer effects of 3, 3'-diindolylmethane (DIM), a compound present in cruciferous vegetables, against ovarian cancer. DIM targets multiple aspects of cancer such as cellcycle regulation and survival, including EGFR-JAK2-STAT3 signaling, checkpoint activation, caspase activation, endoplasmic reticulum stress, autophagy and anoikis. This broad spectrum of anti-cancer activities in conjunction with low systemic toxicity accentuates the translational value of DIM in cancer therapy. Together, our pre-clinical studies demonstrate that DIM has activity against ovarian cancer and hence should be further investigated in clinical setting to exploit its therapeutic potential.
卵巢癌是妇科恶性肿瘤之首，每年估计有超过 22000 例新发病例和 15000 例死亡。由于缺乏足够准确的筛查试验，该病通常在晚期被发现，预后较差。流行病学研究继续支持这样一种观点，即食用十字花科蔬菜可降低卵巢癌的风险。在本综述文章中，我们描述了存在于十字花科蔬菜中的 3,3'-二吲哚甲烷（DIM）对卵巢癌的抗癌作用。DIM 针对癌症的多个方面，如细胞周期调节和存活，包括 EGFR-JAK2-STAT3 信号传导、检查点激活、半胱天冬酶激活、内质网应激、自噬和 anoikis。这种广谱的抗癌活性与低全身毒性相结合，突出了 DIM 在癌症治疗中的转化价值。总之，我们的临床前研究表明 DIM 对卵巢癌具有活性，因此应在临床环境中进一步研究，以利用其治疗潜力。
