Viral Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Travel Med Infect Dis. 2012 Sep;10(5-6):275-8. doi: 10.1016/j.tmaid.2012.08.005. Epub 2012 Nov 10.
An 86-year-old man with history of travel to Guatemala presented with a 4-month history of an enlarging ulcerative lesion on his right ear. After several weeks of empiric treatment for otitis externa, histopathology, culture, and PCR analysis of a biopsy specimen confirmed the diagnosis of localized cutaneous leishmaniasis secondary to Leishmania mexicana. Known as "Chiclero's ulcer" in southeast Mexico and Latin America, this unique presentation of cutaneous leishmaniasis is caused mainly by the L. mexicana complex. Infection results in a single ulcerative lesion, most commonly involving the ear pinna, without a tendency for cutaneous metastasis, lymphatic or mucosal involvement. The majority of cases of "Chiclero's ulcer" spontaneously re-epithelialize without treatment within 3-9 months. This patient's lesion completely resolved without therapy after 11 months. "Chiclero's ulcer" should be considered in the differential diagnosis of a patient presenting with a chronic ulcerative lesion and history of travel to an endemic area.
一位 86 岁的男性,有前往危地马拉的旅行史,其右侧耳部出现了一个 4 个月大的溃疡性病变。在外耳炎的经验性治疗数周后,活检组织的组织病理学、培养和 PCR 分析证实了由 Leishmania mexicana 引起的局限性皮肤利什曼病的诊断。这种独特的皮肤利什曼病在墨西哥东南部和拉丁美洲被称为“Chiclero 的溃疡”,主要由 L. mexicana 复合体引起。感染导致单个溃疡性病变,最常见于耳廓,没有皮肤转移、淋巴或粘膜受累的倾向。大多数“Chiclero 的溃疡”病例在未经治疗的情况下会在 3-9 个月内自发重新上皮化。该患者的病变在 11 个月后未经治疗完全消退。对于出现慢性溃疡性病变和前往流行地区旅行史的患者,应考虑“Chiclero 的溃疡”作为鉴别诊断。