Department of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
J Endod. 2012 Dec;38(12):1581-7. doi: 10.1016/j.joen.2012.09.010. Epub 2012 Oct 23.
This study was conducted to evaluate and compare maturogenesis induced by revascularization with and without platelet-rich plasma (PRP).
Twenty patients with nonvital, immature anterior teeth were randomly categorized into 2 groups. Subsequent to chemomechanical preparation, revascularization with and without PRP carried on a collagen sponge was induced in groups 1 and 2, respectively. The cases were followed up clinically and radiographically at 6- and 12-month intervals.
Clinically, all cases were asymptomatic with complete resolution of signs and symptoms. Radiographically, there was a marked difference in periapical healing, apical closure, and dentinal wall thickening in group 2 in comparison with group 1. However, root lengthening was comparable for both of the procedures.
Revascularization is a conservative and an effective method for inducing maturogenesis in nonvital, immature teeth. Supplementations with PRP can potentially improve the desired biological outcome of this regenerative technique.
本研究旨在评估和比较伴有和不伴有富血小板血浆（PRP）的血管再生诱导的成熟过程。
将 20 名患有非活力、未成熟前牙的患者随机分为 2 组。在第 1 组和第 2 组中，分别在胶原海绵上进行伴有和不伴有 PRP 的血管再生。在 6 个月和 12 个月的时间间隔内进行临床和影像学随访。
临床方面，所有病例均无症状，且所有体征和症状均完全消退。影像学方面，与第 1 组相比，第 2 组根尖愈合、根尖封闭和牙本质壁增厚有明显差异。然而，两种方法的牙根长度增加相似。
血管再生是诱导非活力、未成熟牙齿成熟的一种保守且有效的方法。PRP 的补充可能会改善这种再生技术的预期生物学效果。
