中国河南省女性人乳头瘤病毒（HPV）的流行病学和基因型分布。

Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Henan Province, China.

机构信息

Department of Cytopathology, The Third Affiliated Hospital of Zhengzhou University, PR China.

出版信息

Clin Chim Acta. 2013 Jan 16;415:297-301. doi: 10.1016/j.cca.2012.11.005. Epub 2012 Nov 10.

DOI:10.1016/j.cca.2012.11.005

PMID:23148995

Abstract

BACKGROUND

Human papillomavirus (HPV) infection is the commonest sexually transmitted infection, which is associated with various clinical conditions. This study aimed to determine the distribution of HPV genotypes in the women of Henan Province, China.

METHODS

Cervical samples were collected by liquid-based method and consecutively evaluated cervical cytology and the presence of HPV DNA. Cytological classification was made according to the Bethesda 2001 criteria. HPV DNA was tested with xMAP technology by Luminex200™.

RESULTS

In cervical abnormalities, the infection rate of HPV was 84.0%, single type was 71.0%, multiple type was 13.0%, high risk HPV was 78.0% and low risk HPV was 8.0%. The most common genotypes found were HPV16, 52, 58, 33, 18, 6 and 39. The most common HPV genotypes were HPV16, 52, 6, 58 and 33 in NILM, HPV16, 52, 18, 58 and 6 in ASCUS, HPV52, 16, 58, 6 and 39 in LSIL, HPV16, 33, 58, 18 and 51 in HSIL, and HPV16, 18, 33, 58 and 52 in ICC, respectively. The prevalence of single HPV and multiple HPV was 64.8% and 13.3%, respectively. Age-specific prevalence of multiple HPV exhibited a "U" shaped curve.

CONCLUSIONS

Single HPV genotype infection was predominantly detected in different groups of cervical lesions in Henan Province, and HPV16, 52, 58, 33, 18 and 6 were the priority HPV types.

摘要

背景

人乳头瘤病毒（HPV）感染是最常见的性传播感染，与各种临床情况有关。本研究旨在确定中国河南省妇女 HPV 基因型的分布。

方法

采用液基方法采集宫颈标本，连续评估宫颈细胞学和 HPV DNA 存在情况。细胞学分类按照 2001 年 Bethesda 标准进行。HPV DNA 采用 xMAP 技术通过 Luminex200™进行检测。

结果

在宫颈异常中，HPV 感染率为 84.0%，单一型为 71.0%，多型为 13.0%，高危型 HPV 为 78.0%，低危型 HPV 为 8.0%。最常见的基因型为 HPV16、52、58、33、18、6 和 39。在 NILM 中最常见的 HPV 基因型为 HPV16、52、6、58 和 33，在 ASCUS 中为 HPV16、52、18、58 和 6，在 LSIL 中为 HPV52、16、58、6 和 39，在 HSIL 中为 HPV16、33、58、18 和 51，在 ICC 中为 HPV16、18、33、58 和 52。单一 HPV 和多型 HPV 的患病率分别为 64.8%和 13.3%。多型 HPV 的年龄特异性患病率呈“U”形曲线。