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陶瓷髋关节假体置换术后寻常型银屑病

Psoriasis vulgaris caused by ceramic inserts used in total hip replacement.

机构信息

Department of Orthopedic Surgery, Kurume University Medical Center.

出版信息

J Cutan Med Surg. 2012 Nov-Dec;16(6):448-50. doi: 10.1177/120347541201600618.

Abstract

BACKGROUND

Ceramics are inorganic nonmetallic materials and are used as bioinert components in joint replacement surgeries. Ceramics are known to be low allergenic. We experienced a ceramic-induced psoriasis.

OBJECTIVE

We report a first case of possible ceramic-induced psoriasis caused by a ceramic insert.

METHODS

A 55-year-old female received an implanted ceramic-on-ceramic total hip replacement for osteoarthritis of the right hip joint. Following surgery, she developed psoriatic lesions, which continued for 10 years. We suspected that psoriasis was caused by a ceramic insert and removed it surgically.

RESULTS

When the ceramic insert was replaced with a polyethylene-on-metal hip joint, the psoriatic lesions completely disappeared.

CONCLUSION

The pathogenesis of psoriasis is still an enigma, although deregulation of nuclear factor κB signaling and resulting abnormal cytokine secretion are speculated to be involved. Ceramics may affect these signaling events and cause the onset of psoriasis.

摘要

背景

陶瓷是无机非金属材料,被用作关节置换手术中的生物惰性成分。陶瓷的致敏性较低。我们曾遇到一例陶瓷引发的银屑病。

目的

我们报告首例可能由陶瓷嵌体引起的陶瓷诱导性银屑病。

方法

一名 55 岁女性因右侧髋关节骨关节炎接受了陶瓷对陶瓷全髋关节置换术。手术后,她出现了银屑病病变,持续了 10 年。我们怀疑银屑病是由陶瓷嵌体引起的,并进行了手术切除。

结果

当陶瓷嵌体被聚乙烯对金属髋关节置换体取代后,银屑病病变完全消失。

结论

尽管推测银屑病的发病机制与核因子 κB 信号的失调和由此导致的异常细胞因子分泌有关,但仍不清楚。陶瓷可能会影响这些信号事件并引发银屑病的发生。

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