烧伤后脂肪酸和甘油三酯与严重烧伤儿童临床结局的相关性。
Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children.
机构信息
Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA.
出版信息
J Clin Endocrinol Metab. 2013 Jan;98(1):314-21. doi: 10.1210/jc.2012-2599. Epub 2012 Nov 12.
Abstract
CONTEXT
Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear.
OBJECTIVE
The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses.
DESIGN AND SETTING
We conducted a prospective cohort study at an academic pediatric hospital burn center.
PATIENTS
Our study included 219 pediatric burn patients.
MAIN OUTCOME MEASURES
Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed.
RESULTS
All groups were similar in demographics and injury characteristics. Patients with elevated TGs had significantly worse clinical outcomes associated with increased acute-phase protein synthesis indicating augmented inflammation and hypermetabolism, whereas increased FFAs did not seem to profoundly alter postburn outcomes.
CONCLUSIONS
Elevated TGs, but not FFAs, postburn are associated with worsened organ function and clinical outcomes.
摘要
背景
烧伤后游离脂肪酸（FFAs）和甘油三酯（TGs）会发生改变，但这些改变是否与烧伤后结局相关尚不清楚。
目的
本研究旨在分析小儿烧伤患者的脂代谢谱，并将这些谱与患者结局和住院过程相关联。
设计和设置
我们在一家学术性儿科医院烧伤中心进行了一项前瞻性队列研究。
患者
本研究纳入了 219 例小儿烧伤患者。
主要观察指标
根据患者的血浆 TG 和 FFA 水平对其进行分层。分析主要患者结局，如烧伤后发病率和死亡率，以及临床代谢标志物。
结果
所有组在人口统计学和损伤特征方面均相似。TG 升高的患者临床结局明显较差，与急性期蛋白合成增加相关，表明炎症和高代谢增强，而 FFA 升高似乎并未显著改变烧伤后的结局。
结论
烧伤后 TG 升高而非 FFA 升高与器官功能和临床结局恶化相关。
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