Valdes-Dapena M, Hoffman H J, Froelich C, Requeira O
Department of Pathology, University of Miami School of Medicine, Florida 33101.
Pediatr Pathol. 1990;10(1-2):273-9. doi: 10.3109/15513819009067113.
In the past two decades, two groups of investigators have alleged that infants who die of the sudden infant death syndrome (SIDS) have excess numbers of sclerotic glomeruli in their kidneys. This double blind, case-control study was undertaken to test that assertion. Using microscopic sections of the kidney from 153 autopsies (99 SIDS infants and 54 control infants) in the National Institute of Child Health and Human Development (NICHD) Cooperative Epidemiologic Study of Risk Factors for SIDS, we counted relative numbers of sclerotic glomeruli in four fields of renal cortical tissue in two sections from each infant. Our results indicate that there is no difference between the two groups in regard to the proportion of sclerotic glomeruli.
在过去二十年里，两组研究人员宣称死于婴儿猝死综合征（SIDS）的婴儿肾脏中硬化性肾小球数量过多。开展这项双盲病例对照研究以验证该论断。利用美国国立儿童健康与人类发展研究所（NICHD）婴儿猝死综合征风险因素合作流行病学研究中153例尸检（99例SIDS婴儿和54例对照婴儿）的肾脏显微切片，我们对每个婴儿两片肾皮质组织四个视野中的硬化性肾小球相对数量进行了计数。我们的结果表明，两组在硬化性肾小球比例方面没有差异。
