Variend S, Howat A J
Eur J Pediatr. 1986 Apr;145(1-2):90-3. doi: 10.1007/BF00441864.
Recurrent apnoea and chronic hypoventilation have been implicated in the pathogenesis of the sudden infant death syndrome (SIDS) and markers of chronic hypoxaemia have been reported in such infants at post mortem examination. Markers of chronic hypoxaemia are common in cyanotic congenital heart disease. Glomerular enlargement in congenital heart disease is said to be related to hypoxaemia although the precise mechanism whereby this occurs is not clear. We have established a normal range of glomerular size for the postperinatal period and confirmed glomerular enlargement to be a common finding in children with congenital heart disease of similar age. In contrast glomerular size in SIDS is not different from controls. The results question the role of significant chronic hypoxaemia being involved in these deaths.
反复呼吸暂停和慢性通气不足与婴儿猝死综合征（SIDS）的发病机制有关，且尸检报告显示此类婴儿存在慢性低氧血症的标志物。慢性低氧血症的标志物在青紫型先天性心脏病中很常见。先天性心脏病中的肾小球增大据说是与低氧血症有关，尽管其发生的确切机制尚不清楚。我们已经确定了围生后期肾小球大小的正常范围，并证实肾小球增大在年龄相仿的先天性心脏病患儿中是常见表现。相比之下，SIDS患儿的肾小球大小与对照组并无差异。这些结果对严重慢性低氧血症参与这些死亡事件的作用提出了质疑。
