大气污染对呼吸健康的影响：最新研究进展。

Respiratory health effects of ambient air pollution: an update.

机构信息

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver General Hospital (VGH)-Research Pavilion, Canada.

出版信息

Clin Chest Med. 2012 Dec;33(4):759-69. doi: 10.1016/j.ccm.2012.07.003.

DOI:10.1016/j.ccm.2012.07.003

PMID:23153614

Abstract

There is new evidence for ambient air pollution (AAP) leading to an increased incidence of respiratory diseases in adults. Research has demonstrated that co-exposures have the potential to dramatically augment the effects of AAP and lower the threshold of effect of a given pollutant. Interactions between genes related to oxidative stress and AAP seem to significantly alter the effect of AAP on an individual and population basis. A better definition of vulnerable populations may bolster local or regional efforts to remediate AAP. Advances in genetic research tools have the potential to identify candidate genes that can guide further research.

摘要

有新的证据表明，环境空气污染（AAP）会导致成年人呼吸道疾病发病率上升。研究表明，共同暴露有潜力显著增强 AAP 的影响，并降低特定污染物的影响阈值。与氧化应激相关的基因与 AAP 之间的相互作用似乎会显著改变 AAP 对个体和人群的影响。更好地定义脆弱人群可能会支持当地或地区努力来改善 AAP。遗传研究工具的进步有可能确定候选基因，从而指导进一步的研究。