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最近的狂饮预测青少年小脑体积较小。

Recent binge drinking predicts smaller cerebellar volumes in adolescents.

机构信息

Department of Psychology, University of Wisconsin-Milwaukee, 2241 E. Hartford Ave, Milwaukee, WI 53211, USA.

出版信息

Psychiatry Res. 2013 Jan 30;211(1):17-23. doi: 10.1016/j.pscychresns.2012.07.009. Epub 2012 Nov 13.

Abstract

The current study examined the effects of recent binge drinking on cerebellar morphometry in a sample of healthy adolescents. Participants were 106 teenagers (46 bingers and 60 controls) aged 16-19 who received a high-resolution magnetic resonance imaging (MRI) scan. FreeSurfer segmented and quantified the volume of each cerebellum. Maximum drinks during a binge in the past 3 months and duration since last binge were examined as predictors of cerebellar volume, after controlling for potentially confounding variables. In the 106 teens, higher peak drinks predicted smaller left hemisphere cerebellar gray and whitematter, and right hemisphere cerebellar gray matter, and marginally predicted smaller right hemisphere cerebellar white matter. Gender did not moderate these effects. More intense adolescent binge drinking is linked to smaller cerebellar volumes even in healthy teens, above and beyond variability attributable to risk factors for binge drinking. Longitudinal research is needed to see if cerebellar volumes worsen with protracted drinking and recover with abstinence. Interventions aimed at improving brain structure in adolescent binge drinkers are necessary given the high prevalence of risky drinking in youth.

摘要

本研究考察了近期 binge drinking 对健康青少年小脑形态的影响。参与者为 106 名 16-19 岁的青少年(46 名 binge drinker 和 60 名对照组),他们接受了高分辨率磁共振成像(MRI)扫描。FreeSurfer 对每个小脑的体积进行了分割和量化。在控制潜在混杂变量的情况下,研究了过去 3 个月内 binge drinking 期间的最大饮酒量和最后一次 binge drinking 后的持续时间对小脑体积的预测作用。在 106 名青少年中,较高的 binge drinking 峰值预测左侧小脑灰质和白质以及右侧小脑灰质体积较小,并且略微预测右侧小脑白质体积较小。性别没有调节这些影响。即使在健康青少年中,青少年 binge drinking 越剧烈,小脑体积越小,这超出了 binge drinking 风险因素的可变性。需要进行纵向研究,以观察小脑体积是否会随着长期饮酒而恶化,并在戒酒后恢复。鉴于青少年中危险饮酒的高流行率,有必要针对青少年 binge drinker 开展改善大脑结构的干预措施。

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