McCracken J T, Rubin R T, Poland R E
UCLA School of Medicine, Department of Psychiatry, Harbor UCLA Medical Center, Torrance 90509.
Psychiatry Res. 1990 Jan;31(1):49-56. doi: 10.1016/0165-1781(90)90108-h.
The dexamethasone suppression index (DSI), which is the product of the postdexamethasone (DEX) serum DEX concentration and the post-DEX serum cortisol concentration, has been suggested to be a more sensitive discriminative test for depression than the standard DEX suppression test (DST). We used receiver operating characteristic (ROC) analysis to examine the DSI, calculated in several ways, versus the standard DST in a sample of 40 endogenous major depressives and 40 matched normal control subjects. The ROC analysis indicated that the DSI offers no advantage over the standard DST, regardless of which criterion values are used to define cortisol nonsuppression. Serum DEX determinations appear to have value primarily as an indicator of the minimum DEX concentration necessary for an accurate DST.
地塞米松抑制指数（DSI）是地塞米松（DEX）给药后血清DEX浓度与地塞米松给药后血清皮质醇浓度的乘积，有人认为它是一种比标准地塞米松抑制试验（DST）更敏感的抑郁症鉴别试验。我们采用受试者工作特征（ROC）分析，在40例内源性重度抑郁症患者和40例匹配的正常对照受试者样本中，以几种方式计算DSI，并与标准DST进行比较。ROC分析表明，无论使用何种标准值来定义皮质醇不抑制，DSI都不比标准DST更具优势。血清DEX测定的价值似乎主要在于它是准确进行DST所需的最低DEX浓度的指标。
