Camara M, Seydi M, Dieye T N, Sow P S, Mboup S, Kestens L, Jennes W
Immunology Unit, Laboratory of Bacteriology-Virology, CHU Le Dantec, Cheikh Anta Diop University, Dakar, Senegal.
Int J STD AIDS. 2012 Nov;23(11):810-4. doi: 10.1258/ijsa.2012.011436.
Numerous studies suggest that herpes simplex virus type 2 (HSV-2) increases the risk of HIV-1 infection but recent clinical trials of HSV-2 suppressive therapy failed to show an effect. We assessed the putative association between HSV-2 and HIV-1 in a population of HIV-concordant-negative, HIV-1-discordant and HIV-1-concordant-positive married couples from Dakar, Senegal. In agreement with previous studies, we observed a strong overall association between HSV-2 and HIV-1 (odds ratio 4.61; P < 0.001). However, this association was mainly determined by a low HSV-2 prevalence in HIV-concordant-negative couples compared with HIV-1-discordant and HIV-1-concordant-positive couples (23% versus 59% and 66%, respectively; P < 0.001). We observed no further differences in HSV-2 prevalence between HIV-1-discordant and HIV-1-concordant-positive couples (59% and 66%, respectively; P = 0.483). Neither the index (59% versus 62%, P = 1.000) nor recipient partners (41% versus 63%, P = 0.131) in HIV-1-discordant and HIV-1-concordant-positive couples showed significant differences in HSV-2 prevalence. HSV-2 does not constitute a clear risk factor for HIV-1 infection in this population.
众多研究表明，2型单纯疱疹病毒（HSV - 2）会增加感染HIV - 1的风险，但近期HSV - 2抑制疗法的临床试验未能显示出效果。我们在来自塞内加尔达喀尔的HIV抗体检测结果一致为阴性、HIV - 1抗体检测结果不一致以及HIV - 1抗体检测结果一致为阳性的已婚夫妇群体中，评估了HSV - 2与HIV - 1之间的假定关联。与先前的研究一致，我们观察到HSV - 2与HIV - 1之间存在很强的总体关联（优势比4.61；P < 0.001）。然而，这种关联主要是由HIV抗体检测结果一致为阴性的夫妇中HSV - 2患病率较低所决定的，与HIV - 1抗体检测结果不一致以及HIV - 1抗体检测结果一致为阳性的夫妇相比（分别为23%、59%和66%；P < 0.001）。我们观察到HIV - 1抗体检测结果不一致和HIV - 1抗体检测结果一致为阳性的夫妇之间，HSV - 2患病率没有进一步差异（分别为59%和66%；P = 0.483）。在HIV - 1抗体检测结果不一致和HIV - 1抗体检测结果一致为阳性的夫妇中，无论是指数配偶（59%对62%，P = 1.000）还是接受配偶（41%对63%，P = 0.131），HSV - 2患病率均无显著差异。在该人群中，HSV - 2并非HIV - 1感染的明确危险因素。
