Zanigni Stefano, Giannini Giulia, Melotti Roberto, Pattaro Cristian, Provini Federica, Cevoli Sabina, Facheris Maurizio F, Cortelli Pietro, Pramstaller Peter P
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of Lübeck), Bozen/Bolzano, Italy.
Eur J Neurol. 2014 Sep;21(9):1205-10. doi: 10.1111/ene.12462. Epub 2014 May 20.
A higher prevalence of restless legs syndrome (RLS) in migraineurs has been reported in clinical samples and in two large-scale clinical trials performed on healthcare workers but general population-based studies on this topic are lacking. The aim of this study was to assess the association between migraine and RLS in an Italian rural adult population-based setting.
The presence of migraine and RLS was assessed via a computer-assisted personal interview and self-administered questionnaires according to current diagnostic criteria in 1567 participants of a preliminary phase of an adult population-based study performed in South Tyrol, Italy.
Migraineurs had an increased risk of having RLS also after adjustment for confounding factors such as age, sex, major depression, anxiety and sleep quality (odds ratio 1.79; confidence interval 1.00-3.19; P = 0.049). This association was not modified by aura status and possible causes of secondary RLS. RLS was not significantly associated with tension-type headache.
Restless legs syndrome and migraine were associated in our rural adult population. This association could be explained by a possible shared pathogenic pathway which would implicate new management strategies of these two disorders.
临床样本以及两项针对医护人员开展的大规模临床试验均报告称，偏头痛患者中不安腿综合征（RLS）的患病率较高，但缺乏基于普通人群的相关研究。本研究旨在评估意大利农村成年人群中偏头痛与RLS之间的关联。
在意大利南蒂罗尔进行的一项基于成年人群的研究的初步阶段，通过计算机辅助个人访谈和自填问卷，依据当前诊断标准对1567名参与者的偏头痛和RLS情况进行评估。
在对年龄、性别、重度抑郁、焦虑和睡眠质量等混杂因素进行调整后，偏头痛患者患RLS的风险仍有所增加（比值比1.79；置信区间1.00 - 3.19；P = 0.049）。这种关联不受先兆状态和继发性RLS可能病因的影响。RLS与紧张型头痛无显著关联。
在我们研究的农村成年人群中，不安腿综合征与偏头痛有关联。这种关联可能由一条可能的共同致病途径来解释，这将意味着这两种疾病的新管理策略。
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