Zhou Liangbin, Liu Ling, Tian Tian, Xue Bailin, Yu Rongmin
College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Nat Prod Commun. 2012 Oct;7(10):1331-2.
Two new potential antifungal coumarin glycosides, 6-chlorocoumarin 7-O-beta-D-glucopyranoside (1) and 7-hydroxy-4-trifluoromethyl-coumarin 5-O-beta-D-glucopyranoside (2), were synthesized via enzyme-mediated glycosylation of the respective aglycone, 6-chloro-7-hydroxycoumarin and 5,7-dihydroxy-4-trifluoromethylcoumarin, using transgenic hairy roots of Polygonum multiflorum. Instead of application of the isolated enzyme and exogenous sugar donors, hairy roots of P. multiflorum were successfully adapted as a whole-cell biocatalyst.
