Vignon E, Mathieu P, Broquet P, Louisot P, Richard M
Laboratoire d'Exploration Articulaire, Pavillon F, Hôpital Edouard Herriot, Lyon, France.
Semin Arthritis Rheum. 1990 Feb;19(4 Suppl 1):26-9. doi: 10.1016/0049-0172(90)90082-q.
The activity of stromelysin and collagenase was determined in fibrillated human OA cartilage using labeled proteoglycans and type II collagen as substrates. In vitro paracetamol had no effect on metalloprotease whereas TA induced a significant inhibition of stromelysin. In cartilage and synovium from nine patients treated with TA and nine patients treated with paracetamol during 8 weeks before surgery for hip OA, stromelysin activity was significantly lower in the TA than in the paracetamol group. The results suggest that TA has a potential chondroprotective effect in OA.
使用标记的蛋白聚糖和II型胶原蛋白作为底物，测定了纤维化的人骨关节炎（OA）软骨中基质溶解素和胶原酶的活性。在体外，扑热息痛对金属蛋白酶没有影响，而TA可显著抑制基质溶解素。在髋关节OA手术前8周接受TA治疗的9例患者和接受扑热息痛治疗的9例患者的软骨和滑膜中，TA组的基质溶解素活性显著低于扑热息痛组。结果表明，TA在OA中具有潜在的软骨保护作用。
