Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, The University of Kansas Cancer Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Pharmacol Ther. 2013 Apr;138(1):1-17. doi: 10.1016/j.pharmthera.2012.11.002. Epub 2012 Nov 16.
In the last two decades, the study of epigenetic modification emerged as one of the major areas of cancer treatment targeted by dietary phytochemicals. Recent studies with various types of cancers revealed that the epigenetic modifications are associated with the food source corresponds to dietary phytochemicals. The dietary phytochemicals have been used in Asian countries for thousands of years to cure several diseases including cancer. They have been reported to modulate the several biological processes including histone modification, DNA methylation and non-coding microRNA expression. These events play a vital role in carcinogenesis. Various studies suggest that a number of dietary compounds present in vegetables, spices and other herbal products have epigenetic targets in cancer cells. Dietary phytochemicals have been reported to repair DNA damage by enhancing histone acetylation that helps to restrain cell death, and also alter DNA methylation. These phytochemicals are able to modulate epigenetic modifications and their targets to cure several cancers. Epigenetic aberrations dynamically contribute to cancer pathogenesis. Given the individualized traits of epigenetic biomarkers, the personalized nutrition will help us to prevent various types of cancer. In this review, we will discuss the effect of dietary phytochemicals on genetic and epigenetic modifications and how these modifications help to prevent various types of cancers and improve health outcomes.
在过去的二十年中，研究表观遗传修饰已成为癌症治疗的主要领域之一，其靶向治疗物质是膳食植物化学物。最近对各种类型的癌症进行的研究表明，表观遗传修饰与食物来源有关，而食物来源对应于膳食植物化学物。亚洲国家数千年来一直使用膳食植物化学物来治疗多种疾病，包括癌症。据报道，它们可以调节多种生物过程，包括组蛋白修饰、DNA 甲基化和非编码 microRNA 表达。这些事件在致癌作用中起着至关重要的作用。各种研究表明，蔬菜、香料和其他草药产品中存在的许多膳食化合物是癌细胞中的表观遗传靶标。据报道，膳食植物化学物通过增强组蛋白乙酰化来修复 DNA 损伤，有助于抑制细胞死亡，还可以改变 DNA 甲基化。这些植物化学物质能够调节表观遗传修饰及其靶标，以治疗多种癌症。表观遗传异常动态促进癌症发病机制。鉴于表观遗传生物标志物的个体化特征，个性化营养将有助于我们预防各种类型的癌症。在这篇综述中，我们将讨论膳食植物化学物对遗传和表观遗传修饰的影响，以及这些修饰如何有助于预防各种类型的癌症和改善健康结果。
