Institute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain.
Nutrients. 2022 Dec 9;14(24):5246. doi: 10.3390/nu14245246.
Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.
多酚是一组具有广泛生物学功能和促进健康潜力的植物化学物质。这些化合物存在于大多数植物性食物中，通过摄入营养补充剂、强化食品和饮料，其广泛的可用性也增加了整个孕期的暴露量。在本综述中，我们重点关注多酚在健康和病理妊娠中的作用。首先介绍了它们的分类和功能的一般信息，然后概述了它们在早孕事件中的已知作用，包括目前对涉及的分子机制的了解。此外，我们还概述了它们在一些最常见的与妊娠相关的病理状况中的参与，如子痫前期和妊娠期糖尿病。此外，我们还讨论了多酚消费对妊娠结局的估计可能风险。考虑到多酚对母体适应和胎儿发育过程中涉及的机制的可能影响，在妊娠期间食用膳食多酚需要特别注意。需要进一步的研究来阐明妊娠期间多酚代谢物的体内作用，以及它们在高龄产妇、产前营养和后代代谢风险中的作用。
