Department of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.
J Pain Symptom Manage. 2013 Aug;46(2):282-8. doi: 10.1016/j.jpainsymman.2012.08.008. Epub 2012 Nov 15.
Fatigue, one of the most common side effects of chemotherapy, is typically assessed via retrospective recall (e.g., over the past week). It is unknown how such retrospective recall of fatigue correlates with daily ratings among people receiving chemotherapy.
The current study compared fatigue recorded in daily diaries with retrospective ratings using the Fatigue Symptom Inventory (FSI) in patients receiving chemotherapy for gynecologic cancer.
During the week before and the week after their first infusion of chemotherapy, patients completed daily diaries at 10 AM, 2, and 6 PM and the FSI at the end of each week.
FSI and diary ratings of peak, lowest, and average fatigue were significantly correlated (P < 0.001). When peak, end, average, and variance diary ratings were regressed separately on the average FSI item, each was significant pre-chemotherapy (P < 0.01) and post-chemotherapy (P < 0.05). However, when entered into a stepwise regression model, only the average fatigue diary rating was retained, explaining 52% of the variance pre-chemotherapy and 54% of the variance post-chemotherapy average FSI item (P < 0.001).
The FSI keyed to the past week accurately reflects daily ratings of fatigue among patients receiving chemotherapy. This study has important implications, as completing retrospective ratings of fatigue may be less burdensome for cancer patients than daily assessments.
疲劳是化疗最常见的副作用之一，通常通过回顾性回忆（例如，过去一周）来评估。目前尚不清楚接受化疗的人群中，这种对疲劳的回顾性回忆与日常评分之间的相关性如何。
本研究比较了妇科癌症接受化疗患者的疲劳记录在每日日记中与使用疲劳症状量表（FSI）进行回顾性评分的相关性。
在第一次化疗输注前一周和后一周，患者每天上午 10 点、下午 2 点和 6 点完成每日日记，并在每周结束时完成 FSI。
FSI 和日记的峰值、最低和平均疲劳评分显著相关（P<0.001）。当峰值、结束时、平均和方差日记评分分别回归平均 FSI 项目时，每个评分在化疗前（P<0.01）和化疗后（P<0.05）均显著。然而，当进入逐步回归模型时，只有平均疲劳日记评分被保留，解释了化疗前平均 FSI 项目的 52%和化疗后平均 FSI 项目的 54%的方差（P<0.001）。
FSI 针对过去一周准确反映了接受化疗的患者的日常疲劳评分。这项研究具有重要意义，因为完成对疲劳的回顾性评分可能比每日评估对癌症患者的负担更小。
