Moffitt Cancer Center, Tampa, FL 33612, USA.
Ann Behav Med. 2011 Dec;42(3):321-33. doi: 10.1007/s12160-011-9294-9.
Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown.
The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy.
Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants' first three infusions.
Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps < .05).
This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.
先前的研究表明，癌症患者在化疗过程中经常会出现多种症状；然而，症状变化之间的关系在很大程度上尚不清楚。
本研究旨在考察化疗期间疲劳、抑郁以及客观测量的睡眠和活动中断的日间和日内变化以及相互关系。
参与者为 78 名妇科癌症患者。在参与者接受前三剂化疗之前和之后的一周内，评估了疲劳、抑郁、睡眠和活动情况。
随着时间的推移，疲劳、抑郁、睡眠和活动均出现了显著变化。在输注之前，疲劳的增加与抑郁的增加有关。在输注之后，疲劳的增加与抑郁以及夜间清醒时间的增加、白天活动的减少以及睡眠/活动模式的规律性的降低有关（p<0.05）。
本研究是首次跟踪化疗期间症状的日间和日内变化以及相互关系的研究之一。结果表明，症状相互关联，输注后会恢复到基线水平。
