Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
Org Lett. 2011 Jul 15;13(14):3746-9. doi: 10.1021/ol2014347. Epub 2011 Jun 21.
The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh(2)(oct)(4)/AgOCOCF(3) binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles in good to excellent yields.
首次报道了 1,2,3-三唑与末端炔烃的跨环加成反应生成吡咯。该反应在 Rh(2)(oct)(4)/AgOCOCF(3) 双催化体系存在下进行,为 1,2,4-三取代吡咯提供了一种直接、高产率的方法。