单剂量右美沙芬对精神运动表现和工作记忆能力的影响。
Effect of a single dose of dextromethorphan on psychomotor performance and working memory capacity.
作者信息
Al-Kuraishy Hayder M, Al-Gareeb Ali I, Ashor Ammar Waham
机构信息
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
出版信息
Indian J Psychol Med. 2012 Apr;34(2):140-3. doi: 10.4103/0253-7176.101779.
BACKGROUND
Previous studies show that the prolonged use of dextromethorphan produces cognitive deterioration in humans.
AIM
The aim of this study was to investigate the effect of a single dose of dextroemthrophan on psychomotor performance and working memory capacity.
MATERIALS AND METHODS
This is a randomized, double-blind, controlled, and prospective study. Thirty-six (17 women, 19 men) medical students enrolled in the study; half of them (7 women, 11 men) were given placebo, while the other half (10 women, 8 men) received dextromethorphan. The choice reaction time, critical flicker fusion threshold, and N-back working memory task were measured before and after 2 h of taking the drugs.
RESULTS
Dextromethorphan showed a significant deterioration in the 3-back working memory task (P<0.05). No significant changes were seen as regards the choice reaction time components (total, recognition, motor) and critical flicker fusion threshold (P>0.05). On the other hand, placebo showed no significant changes as regards the choice reaction time, critical flicker fusion threshold, and N-back working memory task (P>0.05).
CONCLUSION
A single dose of dextromethorphan has no effect on attention and arousal but may significantly impair the working memory capacity.
背景
先前的研究表明，长期使用右美沙芬会导致人类认知能力下降。
目的
本研究旨在调查单剂量右美沙芬对心理运动表现和工作记忆能力的影响。
材料与方法
这是一项随机、双盲、对照的前瞻性研究。36名（17名女性，19名男性）医学生参与了该研究；其中一半（7名女性，11名男性）服用安慰剂，另一半（10名女性，8名男性）服用右美沙芬。在服药2小时前后测量选择反应时间、临界闪烁融合阈值和N-回溯工作记忆任务。
结果
右美沙芬在3-回溯工作记忆任务中表现出显著下降（P<0.05）。在选择反应时间成分（总时间、识别时间、运动时间）和临界闪烁融合阈值方面未见显著变化（P>0.05）。另一方面，安慰剂在选择反应时间、临界闪烁融合阈值和N-回溯工作记忆任务方面未见显著变化（P>0.05）。
结论
单剂量右美沙芬对注意力和唤醒无影响，但可能显著损害工作记忆能力。
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