Busch K H, Bender R, Walezko N, Aziz H, Altintas M A, Aust M C
Department for Plastic and Reconstructive Surgery, Johanniter Hospital, Bonn, Germany.
Department for Plastic and Reconstructive Surgery, Bergmannsheil und Kinderklinik Buer, Gelsenkirchen, Germany.
Ann Burns Fire Disasters. 2016 Jun 30;29(2):116-122.
Burn scars remain a serious physical and psychological problem for the affected. Clinical studies as well as basic scientific research have shown that Medical Needling can significantly increase the quality of burn scars with comparatively low risk and stress for the patient with regards to skin elasticity, moisture, erythema and transepidermal water loss. However, Medical Needling has no influence on repigmentation of large hypopigmented scars. The goal is to evaluate whether both established methods - Needling (improvement of scar quality) and ReNovaCell (repigmentation) - can be combined. So far, eight patients with mean age of 20 years (6-28 years) with deep second and third degree burn scars have been treated. The average treated tissue surface was 76cm² (15-250cm²) and was focused on areas like face, neck, chest and arm. Medical Needling is performed using a roller covered with 3mm long needles. The roller is vertically, horizontally and diagonally rolled over the scar, inducing microtrauma. Then, non-cultured autologous skin cell suspension (ReNovaCell) is applied, according to the known protocol. The patients were followed 12 months postoperatively. Pigmentation changes were measured objectively, and with patient and observer ratings. Patient satisfaction/preference was also obtained. We present the final study results. Taken together, pigmentation ratings and objective measures indicate improvement in six of the study participants. Melanin increase seen 12 months after ReNovaCell treatment in the study group as a whole is notable. Medical Needling in combination with ReNovaCell shows promise for repigmentation of burn scars.
烧伤疤痕对患者来说仍然是一个严重的生理和心理问题。临床研究以及基础科学研究表明，医疗针刺能够显著改善烧伤疤痕的质量，对于患者而言，在皮肤弹性、水分、红斑和经表皮水分流失方面，其风险和压力相对较低。然而，医疗针刺对大面积色素减退疤痕的色素沉着没有影响。目标是评估两种既定方法——针刺（改善疤痕质量）和ReNovaCell（色素沉着）——是否可以联合使用。到目前为止，已经对8名平均年龄为20岁（6 - 28岁）的深二度和三度烧伤疤痕患者进行了治疗。平均治疗的组织面积为76平方厘米（15 - 250平方厘米），主要集中在面部、颈部、胸部和手臂等部位。医疗针刺使用覆盖有3毫米长针头的滚轮进行。滚轮在疤痕上垂直、水平和对角滚动，造成微创伤。然后，按照已知方案应用非培养的自体皮肤细胞悬液（ReNovaCell）。术后对患者进行了12个月的随访。客观测量色素沉着变化，并让患者和观察者进行评分。还获得了患者的满意度/偏好。我们展示最终的研究结果。总体而言，色素沉着评分和客观测量表明，6名研究参与者有改善。在整个研究组中，ReNovaCell治疗12个月后观察到黑色素增加显著。医疗针刺联合ReNovaCell在烧伤疤痕色素沉着方面显示出前景。
