Fiedler K, Würfel W, Krüsmann G, Rothenaicher M, Hirsch P, Krüsmann W
Abteilung für Sterilitätsdiagnostik und in-vitro-Fertilisation, Frauenklinik Dr. Krüsmann.
Z Geburtshilfe Perinatol. 1990 Jan-Feb;194(1):8-12.
This record concerns the statistical registration and analysis of the courses and developments having taken place in 246 pregnancies and births after in-vitro-fertilization. The cases were registered retrospectively, the degree of registration being 77.2% approximately; the scientific evaluation was carried out on the basis of the BPE 1987. It can be shown that there is an increased incidence of the EPH-gestosis, the clinically relevant placenta insufficiency syndrome, the intrauterine death of fetus, the abruptio placentae and prematurity. As predisposing factors must primarily be seen and discussed the ovarian hyperstimulation being--in most cases--connected with IVF and the higher age of the patients; it can be supposed that the method of fertilization in vitro itself is of minor importance. Its importance in the pathogenesis of abruptio placentae, however, cannot be exactly evaluated so far. The frequency of multiple pregnancies represents a special problem. Though the rate is lower in the examined group than in comparable--that is due to the limited number of collected oocytes--it should be aimed at a further lowering of multiple pregnancy rates.
本记录涉及对246例体外受精后妊娠和分娩过程的统计登记与分析。这些病例为回顾性登记，登记程度约为77.2%；科学评估是基于1987年的《英国产科学会标准》进行的。结果表明，妊娠高血压综合征、具有临床意义的胎盘功能不全综合征、胎儿宫内死亡、胎盘早剥和早产的发生率有所增加。作为诱发因素，首先必须考虑并讨论与体外受精相关的卵巢过度刺激（在大多数情况下）以及患者年龄较大的问题；可以推测，体外受精方法本身的影响较小。然而，到目前为止，其在胎盘早剥发病机制中的重要性尚无法准确评估。多胎妊娠的发生率是一个特殊问题。尽管在受检组中该比率低于可比组（这是由于收集的卵母细胞数量有限），但仍应致力于进一步降低多胎妊娠率。
