Wiedemann R, Korell M, Strowitzki T, Hepp H
Ludwig-Maximilians-Universität München, Universitäts-Frauenklinik im Klinikum Grosshadern.
Z Geburtshilfe Perinatol. 1990 Jan-Feb;194(1):1-7.
Worldwide analysis of pregnancies after IVF/ET allows the evaluation of the pregnancy outcome compared to normal population. The mean age of IVF-patients is significantly higher. The incidence of clinical abortions after IVF/ET is within normal range, correlating rather with age than with treatment modalities. The rate of multiple gestations is increased after IVF/ET as well as GIFT or hMG-stimulation, leading to more high risk pregnancies. Gestosis is seen in 7% of singletons and 17% of triplet pregnancies. Preterm deliveries before 36 weeks of gestation occur in 17% of singleton and 52% of twin pregnancies after IVF/ET (control 7.3%). This leads to an increasing rate of caesarean section. The global malformation rate is 2% and in a comparable range to normal population. A presumably higher incidence of neural tube defects has to be proven in a larger number of IVF pregnancies.
对体外受精/胚胎移植后妊娠情况进行的全球分析，能够评估与正常人群相比的妊娠结局。体外受精患者的平均年龄显著更高。体外受精/胚胎移植后临床流产的发生率在正常范围内，更多地与年龄相关，而非与治疗方式相关。体外受精/胚胎移植以及配子输卵管内移植或人绝经期促性腺激素刺激后，多胎妊娠率会升高，导致更多高危妊娠。7%的单胎妊娠和17%的三胎妊娠会出现妊娠中毒症。体外受精/胚胎移植后，妊娠36周前的早产在单胎妊娠中占17%，在双胎妊娠中占52%（对照组为7.3%）。这导致剖宫产率上升。总体畸形率为2%，与正常人群处于可比范围。神经管缺陷的发生率可能更高，这有待在更多体外受精妊娠中得到证实。
