Cu(II)催化的 Meldrum's 酸衍生物的有氧过氧氢化及在分子内氧化中的应用：O2/H2 双加氧反应的概念蓝图。
Cu(II)-catalyzed aerobic hydroperoxidation of Meldrum's acid derivatives and application in intramolecular oxidation: a conceptual blueprint for O2/H2 dihydroxylation.
机构信息
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Org Lett. 2012 Dec 7;14(23):5932-5. doi: 10.1021/ol302848m. Epub 2012 Nov 19.
Abstract
Aerobic hydroperoxidation of Meldrum's acid derivatives via a Cu(II)-catalyzed process is presented. The mild reaction conditions are tolerant to pendant unsaturation allowing the formation of endoperoxides via electrophilic activation. Cleavage of the O-O bond provides 1,n-diols with differentiation of the hydroxy groups.
摘要
通过 Cu(II)催化过程实现了梅尔杜姆酸衍生物的需氧氢过氧 化。温和的反应条件对侧链不饱和性具有耐受性，允许通过亲电活化形成内过氧化物。O-O 键的断裂提供了 1,n-二醇，并区分了羟基。
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