National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Republic of Singapore.
Ocul Immunol Inflamm. 2012 Dec;20(6):453-9. doi: 10.3109/09273948.2012.723781. Epub 2012 Nov 19.
To determine quality of life in patients with uveitis and investigate the association between clinical parameters of uveitis and visual functioning.
Prospective cross-sectional study. The interviewer- administered National Eye Institute visual function questionnaire (VFQ-25) was used in 117 adult outpatient uveitic patients. Their scores were compared against 48 controls with no ocular history. Subgroup differences amongst the patients were compared using Mann-Whitney and Kruskal-Wallis test. Multiple regression analysis was performed to determine the associations of visual function and disease characteristics of uveitis.
VFQ-25 composite scores for patients were significantly lower than controls in all domains except driving. In multivariable analysis, lower VFQ-25 composite scores were associated with a chronic course of disease, even after taking into account the influences of visual acuity, treatment regimes and location of disease.
Uveitic patients reported poorer visual functioning. A chronic course of disease is associated with poorer functioning.
评估葡萄膜炎患者的生活质量，并研究葡萄膜炎的临床参数与视觉功能之间的关系。
前瞻性横断面研究。使用访谈员管理的国家眼科研究所视觉功能问卷（VFQ-25）对 117 名成年门诊葡萄膜炎患者进行评估。将他们的评分与 48 名无眼部病史的对照组进行比较。使用 Mann-Whitney 和 Kruskal-Wallis 检验比较患者亚组之间的差异。进行多元回归分析以确定视觉功能和葡萄膜炎疾病特征之间的关联。
除驾驶外，患者的 VFQ-25 综合评分在所有领域均明显低于对照组。在多变量分析中，即使考虑到视力、治疗方案和疾病部位的影响，慢性疾病病程也与较低的 VFQ-25 综合评分相关。
葡萄膜炎患者报告的视觉功能较差。慢性病程与较差的功能相关。
