School of Chemistry and Pharmaceutical Engineering, Shandong Polytechnic University, Jinan 250353, P.R. China.
J Org Chem. 2012 Dec 7;77(23):10745-51. doi: 10.1021/jo3021105. Epub 2012 Nov 28.
An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag(2)CO(3)-catalyzed, three-component domino reaction. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the imidazo[1,2-a]pyridine privileged structure.
一种高效的串联途径已经被开发出来，用于合成环嗪家族的 3H-1,2a(1),3-三氮杂吖庚因衍生物。通过 Yb(OTf)(3)/Ag(2)CO(3)催化的三组分串联反应，可以以中等至良好的收率获得目标化合物。这将为该有用反应在合成含有咪唑并[1,2-a]吡啶优势结构的结构多样的多杂环骨架中的广泛应用奠定基础。
