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通过多米诺反应高效合成吖[1,2-]吲哚衍生物。

An Efficient Synthesis of Acenaphtho[1,2-]indole Derivatives via Domino Reaction.

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

出版信息

Molecules. 2018 Nov 21;23(11):3045. doi: 10.3390/molecules23113045.

DOI:10.3390/molecules23113045
PMID:30469372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6278500/
Abstract

A concise and efficient synthesis of acenaphtho[1,2-]indole derivatives via the domino reactions of enaminones with acenaphthoquinone catalyzed by l-proline has been developed. This protocol has the advantages of good yields, operational convenience and high regioselectivity.

摘要

通过脯氨酸催化的烯胺酮与吖萘醌的多米诺反应，简洁高效地合成了吖萘并[1,2-]吲哚衍生物。该方法具有产率高、操作方便、区域选择性高等优点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/0057d2c54816/molecules-23-03045-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/9f3f7668876a/molecules-23-03045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/8cf12e99b34f/molecules-23-03045-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/0057d2c54816/molecules-23-03045-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/9f3f7668876a/molecules-23-03045-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/8cf12e99b34f/molecules-23-03045-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa6/6278500/0057d2c54816/molecules-23-03045-sch002.jpg

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Selective synthesis of polyfunctionalized pyrido[2,3-b]indoles by multicomponent domino reactions.通过多组分多米诺反应选择性合成多官能化吡啶并[2,3 - b]吲哚。
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Ultrasound-promoted one-pot, four-component synthesis of pyridin-2(1H)-one derivatives.
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Synthesis of 2,5-asymmetrically substituted 3,4-diaminothieno[2,3-b]thiophenes by domino reaction.通过多米诺反应合成2,5-不对称取代的3,4-二氨基噻吩并[2,3-b]噻吩
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