通过多米诺反应高效合成吖[1,2-]吲哚衍生物。
An Efficient Synthesis of Acenaphtho[1,2-]indole Derivatives via Domino Reaction.
机构信息
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
出版信息
Molecules. 2018 Nov 21;23(11):3045. doi: 10.3390/molecules23113045.
Abstract
A concise and efficient synthesis of acenaphtho[1,2-]indole derivatives via the domino reactions of enaminones with acenaphthoquinone catalyzed by l-proline has been developed. This protocol has the advantages of good yields, operational convenience and high regioselectivity.
摘要
通过脯氨酸催化的烯胺酮与吖萘醌的多米诺反应，简洁高效地合成了吖萘并[1,2-]吲哚衍生物。该方法具有产率高、操作方便、区域选择性高等优点。
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