Agboola A
J Natl Med Assoc. 1979 Oct;71(10):935-7.
A clinical study of trophoblastic neoplasia in a Nigerian population in Lagos over a four-year period is reported. A high incidence of one in 379 deliveries for benign trophoblastic tumor and one in 846 deliveries for malignant tumor was found. Seventeen percent of benign trophoblastic tumors in this series progressed to the malignant type, but malignant trophoblastic tumor was preceded by the benign type (hydatidiform mole) in 46 percent of cases. The anterior vaginal wall is a common site for metastases of malignant trophoblastic neoplasia and, in one patient, the lesion progressed further to form a vesicovaginal fistula. While the management of benign disease was conservative, all cases of malignant trophoblastic neoplasia received chemotherapy.
本文报道了在拉各斯的尼日利亚人群中进行的一项为期四年的滋养细胞肿瘤临床研究。发现良性滋养细胞肿瘤的发病率为每379例分娩中有1例，恶性肿瘤的发病率为每846例分娩中有1例。该系列中17%的良性滋养细胞肿瘤进展为恶性类型，但46%的恶性滋养细胞肿瘤之前有良性类型（葡萄胎）。阴道前壁是恶性滋养细胞肿瘤转移的常见部位，在1例患者中，病变进一步发展形成膀胱阴道瘘。良性疾病的治疗是保守的，所有恶性滋养细胞肿瘤病例均接受化疗。
