He Wenwu, Long Jianxiong, Xian Lei, Pang Feng, Su Li, Wei Shixiu, Wei Bo, Hu Yanling
Department of Cardiothoracic Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi;
Exp Ther Med. 2012 Oct;4(4):569-576. doi: 10.3892/etm.2012.640. Epub 2012 Jul 18.
Lung cancer is the most common diagnosed malignancy and the leading cause of cancer-related mortality worldwide. Murine double minute 2 (MDM2) SNP309 polymorphisms have been reported to influence the risk of lung cancer. However, the published studies together with four subsequent meta-analyses have yielded contradictory results. To examine this inconsistency, we conducted a meta-analysis of 6,696 lung cancer cases and 7,972 controls from eight published case-control studies using METAGEN. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with STATA software and used to assess the strength of the association. In the overall analysis, a significant association between MDM2 SNP309 polymorphism and lung cancer risk was observed (OR, 1.143; 95% CI, 1.047-1.247). Moreover, stratified by ethnicity, a significant association was found in Asians (OR, 1.260; 95% CI, 1.111-1.429), but not in Europeans. Subgroup analysis of gender, histology and smoking status suggested that the MDM2 SNP309 genotype was associated with increased lung cancer risk in women (OR, 1.282; 95% CI, 1.062-1.548) and never smokers (OR, 1.328; 95% CI, 1.119-1.575). No statistically significant association was observed in males and ever smoking population, and no association was found in subgroup analysis based on histology. In conclusion, the association between MDM2 SNP309 and lung cancer was statistically significant, particularly in Asians, women and never smoking population.
肺癌是全球最常见的确诊恶性肿瘤，也是癌症相关死亡的主要原因。据报道，鼠双微体2（MDM2）SNP309多态性会影响肺癌风险。然而，已发表的研究以及随后的四项荟萃分析得出了相互矛盾的结果。为了检验这种不一致性，我们使用METAGEN对八项已发表的病例对照研究中的6696例肺癌病例和7972例对照进行了荟萃分析。使用STATA软件计算了具有95%置信区间（CI）的比值比（OR），并用于评估关联强度。在总体分析中，观察到MDM2 SNP309多态性与肺癌风险之间存在显著关联（OR，1.143；95%CI，1.047 - 1.247）。此外，按种族分层后，在亚洲人中发现了显著关联（OR，1.260；95%CI，1.111 - 1.429），但在欧洲人中未发现。按性别、组织学和吸烟状况进行的亚组分析表明，MDM2 SNP309基因型与女性（OR，1.282；95%CI，1.062 - 1.548）和从不吸烟者（OR，1.328；95%CI，1.119 - 1.575）的肺癌风险增加有关。在男性和曾经吸烟人群中未观察到统计学上的显著关联，在基于组织学的亚组分析中也未发现关联。总之，MDM2 SNP309与肺癌之间的关联具有统计学意义，特别是在亚洲人、女性和从不吸烟人群中。
