Chen Weifeng, Wu Qianlan, Ren Hongbo
Department of Neurosurgery, Central Hospital of Handan, Handan, Hebei 056000, P.R. China.
Graduate School of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Biomed Rep. 2014 Jan;2(1):105-111. doi: 10.3892/br.2013.181. Epub 2013 Oct 7.
Epidemiological studies have been conducted to evaluate genetic variations of murine double minute 2 (MDM2) SNP309 associated with the risk of gastric cancer (GC), although evidence remains conflicting. To gain a better understanding of this relationship, a meta-analysis was performed. Several electronic databases were searched up to February 2013, in order to identify relevant case-control studies. Seven published case-control studies with 2,199 cases and 3,201 controls were included. In the overall analysis, significant associations between the MDM2 SNP309 variant and GC risk were found for G vs. T alleles (OR=1.35; 95% CI, 1.24-1.47), GG vs. TT (OR=1.88; 95% CI, 1.59-2.24), recessive model (OR=1.71; 95% CI, 1.49-1.96). Furthermore, stratified by cancer site, significant associations were observed in gastric cardia cancer for all the models, although no significant association was found in any of the models among non-gastric cardia cancer, with the exception of the recessive model. In the subgroup analysis by source of control, MDM2 SNP309 was associated with increased GC risk for the hospital-based case-control (HCC) study for the GG vs. TT, recessive model and for the population-based case-control (PCC) study for the GG vs. TT, recessive model. Following stratification by gender and infection status of (HP) for the recessive model, a significant association was found only in the HP-positive infected individuals. However, no statistically significant association was observed in males, females or the HP-negative infected individuals. In summary, the association between MDM2 SNP309 and GC risk was statistically significant, particularly in gastric cardia cancer for the HP-positive population group.
已经开展了流行病学研究来评估鼠双微体2（MDM2）SNP309的基因变异与胃癌（GC）风险之间的关系，尽管证据仍然存在冲突。为了更好地理解这种关系，进行了一项荟萃分析。检索了截至2013年2月的几个电子数据库，以识别相关的病例对照研究。纳入了7项已发表的病例对照研究，共2199例病例和3201例对照。在总体分析中，发现MDM2 SNP309变异与GC风险之间存在显著关联，具体为G与T等位基因（比值比[OR]=1.35；95%可信区间[CI]，1.24 - 1.47）、GG与TT（OR=1.88；95%CI，1.59 - 2.24）、隐性模型（OR=1.71；95%CI，1.49 - 1.96）。此外，按癌症部位分层后，在贲门癌的所有模型中均观察到显著关联，尽管在非贲门癌的任何模型中，除隐性模型外，均未发现显著关联。在按对照来源进行的亚组分析中，对于GG与TT、隐性模型，MDM2 SNP309与基于医院的病例对照（HCC）研究中的GC风险增加相关，对于GG与TT、隐性模型，与基于人群的病例对照（PCC）研究中的GC风险增加相关。在按隐性模型的性别和幽门螺杆菌（HP）感染状态分层后，仅在HP阳性感染个体中发现显著关联。然而，在男性、女性或HP阴性感染个体中未观察到统计学上的显著关联。总之，MDM2 SNP
309与GC风险之间的关联具有统计学意义，特别是在HP阳性人群组的贲门癌中。
