Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.
Viruses. 2012 Sep;4(9):1537-1547. doi: 10.3390/v4091537. Epub 2012 Sep 13.
Epstein-Barr virus (EBV) immortalizes host cells as part of its latent mode of infection. As a result of this ability to promote cell proliferation and survival, EBV infection contributes to the development of several kinds of B-cell lymphomas and epithelial tumours. The EBV Epstein-Barr nuclear antigen 1 (EBNA1) protein is the only EBV protein expressed in all EBV-associated tumours and plays multiple important roles in EBV latency. In addition to its well-studied roles in viral DNA replication, segregation and transcriptional activation, several studies have identified roles of EBNA1 in manipulating cellular processes that result in reduced apoptosis and increased cell survival. This review discusses these cellular effects of EBNA1 and mechanisms by which they occur.
EB 病毒（EBV）通过潜伏感染的方式使宿主细胞永生化。由于其促进细胞增殖和存活的能力，EBV 感染导致了多种 B 细胞淋巴瘤和上皮肿瘤的发生。EBV 的 Epstein-Barr 核抗原 1（EBNA1）蛋白是所有 EBV 相关肿瘤中唯一表达的 EBV 蛋白，在 EBV 潜伏中发挥多种重要作用。除了在病毒 DNA 复制、分离和转录激活方面的作用外，几项研究还确定了 EBNA1 在操纵细胞过程中的作用，这些过程导致细胞凋亡减少和细胞存活增加。本综述讨论了 EBNA1 的这些细胞效应及其发生机制。
