EB病毒核抗原1
EBNA1.
作者信息
Frappier Lori
机构信息
Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
出版信息
Curr Top Microbiol Immunol. 2015;391:3-34. doi: 10.1007/978-3-319-22834-1_1.
Epstein-Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with specific DNA sequences in the viral episomes. EBNA1 also interacts with several cellular proteins to modulate the activities of multiple cellular pathways important for viral persistence and cell survival. These cellular effects are also implicated in oncogenesis, suggesting a direct role of EBNA1 in the development of EBV-associated tumors.
爱泼斯坦-巴尔核抗原1（EBNA1）在EB病毒潜伏感染中发挥多种重要作用，并且也已被证明会影响EB病毒的裂解感染。EBNA1是EB病毒基因组在潜伏感染中稳定持续存在所必需的，它通过与病毒附加体中的特定DNA序列相互作用来激活其他EB病毒潜伏基因的表达。EBNA1还与几种细胞蛋白相互作用，以调节对病毒持续存在和细胞存活至关重要的多个细胞途径的活性。这些细胞效应也与肿瘤发生有关，表明EBNA1在EB病毒相关肿瘤的发展中起直接作用。
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