Ordoñez Francisco Javier, Fornieles-Gonzalez Gabriel, Rosety Miguel Angel, Rosety Ignacio, Diaz Antonio, Rosety-Rodriguez Manuel
University of Cadiz, School of Sports Medicine, Cadiz, Spain.
Int J Sports Physiol Perform. 2012 Nov 19.
Recent studies have reported that obese young people with Down syndrome suffer from low-grade systemic inflammation. Whereas this condition may be improved in the general population by regular exercise, the problem has received no attention in the case of people with intellectual disability. Therefore, our aim was to assess the influence of aerobic training on plasma adipokines in obese women with Down syndrome. Twenty obese young women with Down syndrome volunteered for this study, eleven of whom were randomly assigned to a 10-week aerobic training programme. They attended 3 sessions/week, which consisted of warm-up exercises followed by the main activity on a treadmill (30-40 min) at a work intensity of 55-65% of peak heart rate, and ended with a cooling-down period. The control group included 9 women with Down syndrome matched for age, sex and BMI. Fat mass percentage and distribution were measured and plasma adipokine levels (leptin and adiponectin) were assessed. In addition, each participant performed a maximal graded continuous treadmill exercise test. These parameters were assessed pre- and post-intervention. This protocol was approved by an Institutional Ethics Committee. Aerobic training produced a significant increase in participants' VO2max (20.2±5.8vs.23.7±6.3ml/kg/min;p<0.001), and plasma leptin levels were significantly reduced in the intervention group (54.2±6.7vs.45.7±6.1ng/ml;p=0.026). Further significant correlations between plasma leptin and indices of obesity were found. In contrast, no significant changes were found in adiponectin levels (p>0.05). None of tested parameters changed in the control group. In conclusion, a 10-week training programme reduced leptin levels in obese young women with Down syndrome.
最近的研究报告称，患有唐氏综合征的肥胖年轻人存在低度全身炎症。虽然在普通人群中，定期锻炼可能会改善这种情况，但对于智障人士，这个问题尚未得到关注。因此，我们的目的是评估有氧训练对患有唐氏综合征的肥胖女性血浆脂肪因子的影响。20名患有唐氏综合征的肥胖年轻女性自愿参加了这项研究，其中11人被随机分配到一个为期10周的有氧训练项目中。她们每周参加3次训练课程，包括热身运动，然后在跑步机上进行主要活动（30 - 40分钟），工作强度为心率峰值的55 - 65%，最后是冷却期。对照组包括9名年龄、性别和体重指数相匹配的患有唐氏综合征的女性。测量了体脂百分比和分布情况，并评估了血浆脂肪因子水平（瘦素和脂联素）。此外，每位参与者都进行了一次最大分级连续跑步机运动测试。这些参数在干预前后进行了评估。该方案已获得机构伦理委员会的批准。有氧训练使参与者的最大摄氧量显著增加（20.2±5.8对23.7±6.3毫升/千克/分钟；p<0.001），干预组的血浆瘦素水平显著降低（54.2±6.7对45.7±6.1纳克/毫升；p = 0.026）。还发现血浆瘦素与肥胖指标之间存在进一步的显著相关性。相比之下，脂联素水平没有显著变化（p>0.05）。对照组的所有测试参数均未改变。总之，为期10周的训练计划降低了患有唐氏综合征的肥胖年轻女性的瘦素水平。
