Ordonez F J, Rosety M A, Camacho A, Rosety I, Diaz A J, Fornieles G, Garcia N, Rosety-Rodriguez M
School of Sports Medicine, University of Cadiz, Cadiz, Spain.
J Intellect Disabil Res. 2014 Jun;58(6):583-90. doi: 10.1111/jir.12056. Epub 2013 Jun 7.
Obesity is a major health problem in people with intellectual disabilities. It is also widely accepted that low-grade systemic inflammation associated to obesity plays a key role in the pathogenic mechanism of several disorders. Fortunately, physical activity has shown to improve inflammation in people with metabolic syndrome and type 2 diabetes. Accordingly, we assessed the influence of aerobic training on pro-inflammatory cytokines and acute phase proteins in women with Down syndrome.
To achieve this outcome, 20 premenopausal obese young women with Down syndrome volunteered for this study. Eleven were randomly assigned to the intervention group and performed a 10-week aerobic training programme, three sessions per week, consisting of a warm-up then a 30- to 40-min treadmill exercise at a work intensity of 55-65% of peak heart rate followed by a cooling-down period. The control group included nine age-, sex- and body mass index-matched women with Down syndrome. Fat mass percentage and fat distribution were measured. Plasmatic levels of tumour necrosis factor (TNF)-α, interleukin (IL)-6 and fibrinogen were assessed by commercial enzyme-linked immunosorbent assay kits. C-reactive protein (CRP) was assessed by nephelometry.
Plasmatic levels of TNF-α (11.7 ± 1.6 vs. 9.2 ± 1.3 pg/ml; P = 0.022), IL-6 (8.2 ± 1.1 vs. 6.1 ± 0.9 pg/ml; P = 0.014) and high sensitive CRP (0.62 ± 0.11 vs. 0.53 ± 0.09 mg/dl; P = 0.009) were significantly reduced in the intervention group. Further, significant correlations between plasmatic and anthropometric parameters were found.
A 10-week training programme reduced pro-inflammatory cytokines and acute phase proteins in obese young women with Down syndrome. Long-term, well-conducted studies are still required to determine whether correction of this low-grade inflammation improves clinical outcomes of women with trisomy 21.
肥胖是智障人群中的一个主要健康问题。人们也普遍认为，与肥胖相关的低度全身炎症在多种疾病的致病机制中起关键作用。幸运的是，体育活动已被证明可改善代谢综合征和2型糖尿病患者的炎症。因此，我们评估了有氧训练对唐氏综合征女性促炎细胞因子和急性期蛋白的影响。
为实现这一目标，20名绝经前肥胖的唐氏综合征年轻女性自愿参与本研究。11名被随机分配到干预组，进行为期10周的有氧训练计划，每周三次，包括热身，然后在工作强度为峰值心率的55%-65%的情况下进行30至40分钟的跑步机运动，随后是冷却期。对照组包括9名年龄、性别和体重指数匹配的唐氏综合征女性。测量了体脂百分比和脂肪分布。通过商业酶联免疫吸附测定试剂盒评估血浆肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6和纤维蛋白原水平。通过散射比浊法评估C反应蛋白（CRP）。
干预组血浆TNF-α（11.7±1.6对9.2±1.3 pg/ml；P=0.022）、IL-6（8.2±1.1对6.1±0.9 pg/ml；P=0.014）和高敏CRP（0.62±0.11对0.53±0.09 mg/dl；P=0.009）水平显著降低。此外，还发现血浆和人体测量参数之间存在显著相关性。
为期10周的训练计划降低了肥胖唐氏综合征年轻女性的促炎细胞因子和急性期蛋白。仍需要长期、精心开展的研究来确定这种低度炎症的纠正是否能改善21三体综合征女性的临床结局。
