Department of Physical Education, University of Qom, Qom, Iran.
Biol Sport. 2013 Mar;30(1):21-7. doi: 10.5604/20831862.1029817. Epub 2013 Jan 21.
The aim of this study was to investigate the effect of 12 weeks of aerobic training on the serum levels of adiponectin and leptin and on inflammatory markers of coronary heart disease in obese men. Sixteen non-athlete obese men were randomly assigned to one of two experimental groups. The experimental group underwent aerobic training consisting of three sessions per week for 12 weeks, while the control group did not participate in the training programme during the study period. Five millilitres of venous blood was taken from each participant at the beginning of the study, during week six and at the end of week 12 to measure the levels of leptin, adiponectin, C-reactive protein, interleukin-6 and tumour necrosis factor-α. The findings showed that aerobic training led to decreases in the levels of CRP (P = 0.002), IL-6 (P = 0.001) and leptin (P = 0.003) and an increase in the level of adiponectin (P = 0.002) in the experimental group relative to the control group. In addition, the level of TNF-α decreased in the experimental group after the 12-week aerobic training period, although this change was not statistically significant. According to the results of this study, regular aerobic exercise decreases the potential risk of coronary heart disease by improving the plasma levels of IL-6, adiponectin, leptin and CRP. Additionally, aerobic exercise can be used as effective non-pharmacological treatment to prevent diseases.
本研究旨在探讨 12 周有氧运动训练对肥胖男性血清脂联素和瘦素水平及冠心病炎症标志物的影响。16 名非运动员肥胖男性被随机分配到两个实验组中的一个。实验组每周进行 3 次有氧运动训练，共 12 周，而对照组在研究期间不参加训练计划。在研究开始时、第 6 周和第 12 周结束时，从每个参与者抽取 5 毫升静脉血，以测量瘦素、脂联素、C 反应蛋白、白细胞介素-6 和肿瘤坏死因子-α的水平。研究结果表明，与对照组相比，有氧运动训练导致实验组 CRP（P=0.002）、IL-6（P=0.001）和瘦素（P=0.003）水平降低，脂联素水平升高（P=0.002）。此外，实验组在 12 周有氧运动训练后 TNF-α水平下降，但这一变化无统计学意义。根据这项研究的结果，定期的有氧运动可以通过改善血浆中 IL-6、脂联素、瘦素和 CRP 的水平，降低冠心病的潜在风险。此外，有氧运动可以作为有效的非药物治疗方法来预防疾病。
