School of Sports Medicine, University of Cadiz, Cadiz, Spain.
Int J Sport Nutr Exerc Metab. 2013 Jun;23(3):239-44. Epub 2012 Nov 19.
Recent studies have reported that obese young people with Down syndrome suffer from low-grade systemic inflammation. Whereas this condition may be improved in the general population by regular exercise, the problem has received no attention in the case of people with intellectual disability. Therefore, the authors' aim was to assess the influence of aerobic training on plasma adipokines in obese women with Down syndrome. Twenty obese young women with Down syndrome volunteered for this study, 11 of whom were randomly assigned to a 10-wk aerobic-training program. They attended 3 sessions/wk, which consisted of warm-up exercises followed by the main activity on a treadmill (30-40 min) at a work intensity of 55-65% of peak heart rate and ended with a cooling-down period. The control group included 9 women with Down syndrome matched for age, sex, and body-mass index. Fat-mass percentage and distribution were measured, and plasma adipokine levels (leptin and adiponectin) were assessed. In addition, each participant performed a maximal graded continuous treadmill exercise test. These parameters were assessed pre- and postintervention. Aerobic training produced a significant increase in participants' maximal oxygen uptake (20.2 ± 5.8 vs.23.7 ± 6.3 ml · kg-1 · min-1; p < .001), and plasma leptin levels were significantly reduced in the intervention group (54.2 ± 6.7 vs.45.7 ± 6.1 ng/ml; p = .026). Further significant correlations between plasma leptin and indices of obesity were found. In contrast, no significant changes were found in adiponectin levels (p > .05). None of the tested parameters changed in the control group. In conclusion, a 10-week training program reduced leptin levels in obese young women with Down syndrome.
最近的研究报告称，患有唐氏综合征的肥胖年轻人患有低度系统性炎症。虽然这种情况在普通人群中可以通过定期运动得到改善，但智障人士的问题却没有得到关注。因此，作者的目的是评估有氧运动对肥胖唐氏综合征女性血浆脂肪因子的影响。20 名肥胖的唐氏综合征年轻女性自愿参加了这项研究，其中 11 名女性被随机分配到 10 周的有氧运动计划中。她们每周参加 3 次课程，包括热身运动，然后在跑步机上进行主要活动（30-40 分钟），工作强度为最大心率的 55-65%，最后是冷却期。对照组包括 9 名唐氏综合征女性，年龄、性别和体重指数相匹配。测量脂肪量百分比和分布，并评估血浆脂肪因子水平（瘦素和脂联素）。此外，每位参与者都进行了最大分级连续跑步机运动测试。这些参数在干预前后进行评估。有氧运动使参与者的最大摄氧量显著增加（20.2 ± 5.8 对 23.7 ± 6.3 ml·kg-1·min-1；p <.001），干预组的血浆瘦素水平显著降低（54.2 ± 6.7 对 45.7 ± 6.1 ng/ml；p =.026）。还发现血浆瘦素与肥胖指数之间存在显著相关性。相比之下，脂联素水平没有显著变化（p >.05）。对照组的所有测试参数均未发生变化。总之，10 周的训练计划降低了肥胖唐氏综合征年轻女性的瘦素水平。
