Ahern M J, Roberts-Thomson P J, Bradley J, Story C, Seshadri P
Department of Immunology/Rheumatology, Flinders Medical Centre, Adelaide, Australia.
Ann Rheum Dis. 1990 Feb;49(2):103-6. doi: 10.1136/ard.49.2.103.
Phenotypic and genotypic characteristics of the peripheral blood mononuclear cells in nine patients with Felty's syndrome have been examined. One patient had an increased number and percentage of peripheral blood mononuclear cells with the phenotype CD3+ Leu-7+ CD16+ and showed a clonal rearrangement of the T cell receptor B chain gene. The remaining eight patients all showed a germline configuration of the T cell receptor B chain gene. In two patients an increased proportion of CD3+ Leu-7+ CD16- peripheral blood mononuclear cells (45 (SD 11)% of peripheral blood mononuclear cells) were found, while the remaining six patients had proportions of CD3+ Leu-7+ cells similar to those of patients with uncomplicated rheumatoid arthritis. These data confirm that patients with Felty's syndrome are heterogeneous, with at least three different peripheral blood mononuclear cell phenotypic subsets. One subset is characterised by a clonal expansion of an unusual lymphocyte subpopulation, another by polyclonal expansion, and the third subset has the same proportions of peripheral blood mononuclear cells as patients with uncomplicated rheumatoid arthritis.
对9例费尔蒂综合征患者外周血单个核细胞的表型和基因型特征进行了检测。1例患者外周血单个核细胞中具有CD3+Leu-7+CD16+表型的细胞数量和百分比增加，并显示T细胞受体β链基因的克隆重排。其余8例患者T细胞受体β链基因均呈种系构型。2例患者外周血中CD3+Leu-7+CD16-单个核细胞比例增加（占外周血单个核细胞的45%（标准差11%）），而其余6例患者CD3+Leu-7+细胞比例与无并发症类风湿关节炎患者相似。这些数据证实，费尔蒂综合征患者具有异质性，至少有三种不同的外周血单个核细胞表型亚群。一个亚群的特征是异常淋巴细胞亚群的克隆性扩增，另一个是多克隆性扩增，第三个亚群的外周血单个核细胞比例与无并发症类风湿关节炎患者相同。
