Université Paris V (Paris Descartes), 2 rue de l'École de Médecine, 75006 Paris, France.
Nat Rev Mol Cell Biol. 2012 Dec;13(12):780-8. doi: 10.1038/nrm3479.
Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria have developed not only the capacity to control distinct molecular cascades leading to cell death but also the ability to sense (and react to) multiple situations of cellular stress, including viral infection. In addition, mitochondria can emit danger signals that alert the cell or the whole organism of perturbations in homeostasis, hence promoting the induction of cell-intrinsic or systemic adaptive responses, respectively. As such, mitochondria can be considered as master regulators of danger signalling.
在超过 15 亿年的专性内共生共同进化过程中，线粒体不仅发展出了控制导致细胞死亡的不同分子级联的能力，还发展出了感知（并对）多种细胞应激情况（包括病毒感染）的能力。此外，线粒体可以发出危险信号，提醒细胞或整个生物体体内平衡的波动，从而分别促进细胞内固有或全身适应性反应的诱导。因此，线粒体可以被认为是危险信号的主要调节者。
