Komada H, Kise Y, Nakagawa M, Yamamura M, Hioki K, Yamamoto M
Department of Surgery, Kansai Medical University, Osaka, Japan.
Cancer Res. 1990 Apr 15;50(8):2418-22.
The influence of dietary molybdenum on esophageal carcinogenesis induced by N-methyl-N-benzylnitrosamine (2.5 mg per kg of body weight once a week for 20 wk s.c.) was studied in male F344 rats. The tumor incidence and tumor development in the esophagus were significantly lower in the rats in the high-molybdenum (2 ppm) diet group than in the rats in the low-molybdenum (0.032 ppm) diet group; i.e., 44.4% (0.6 +/- 0.8) and 73.2% (2.2 +/- 2.0), respectively. The molybdenum levels in the esophagus-forestomach, liver, and serum were significantly higher in the high-molybdenum diet group than in the low-molybdenum diet group. Xanthine oxidase activity in the esophagus and forestomach in the high-molybdenum diet group was significantly higher than that in the low-molybdenum diet group, whereas liver and serum xanthine oxidase activities were not significantly different between these two groups. These results suggest that xanthine oxidase in the esophagus plays a significant role in the inhibitory effect of molybdenum on esophageal carcinogenesis.
在雄性F344大鼠中研究了膳食钼对N-甲基-N-苄基亚硝胺（每周一次，皮下注射，剂量为每千克体重2.5毫克，共20周）诱导的食管癌发生的影响。高钼（2 ppm）饮食组大鼠食管的肿瘤发生率和肿瘤进展显著低于低钼（0.032 ppm）饮食组大鼠；即分别为44.4%（0.6±0.8）和73.2%（2.2±2.0）。高钼饮食组大鼠食管-前胃、肝脏和血清中的钼水平显著高于低钼饮食组。高钼饮食组食管和前胃中的黄嘌呤氧化酶活性显著高于低钼饮食组，而这两组之间肝脏和血清中的黄嘌呤氧化酶活性无显著差异。这些结果表明，食管中的黄嘌呤氧化酶在钼对食管癌发生的抑制作用中起重要作用。
