透明质酸促进鸡胚成纤维细胞和成软骨细胞的表达。
Hyaluronic acid promotes chick embryo fibroblast and chondroblast expression.
作者信息
Cortivo R, De Galateo A, Castellani I, Brun P, Giro M G, Abatangelo G
机构信息
Institute of Histology and Embryology, University of Padua, Italy.
出版信息
Cell Biol Int Rep. 1990 Feb;14(2):111-22. doi: 10.1016/0309-1651(90)90028-w.
15-day-chick-embryo fibroblasts and chondroblasts were cultured in the presence of high and low molecular weight exogenous hyaluronic acid (HA). Growth range and incorporation of radiolabelled sulphate and proline were determined. HA reduced cell proliferation to about 75% of controls, while incorporation of radiolabelled sulphate and proline was higher in HA-treated cultures of both chondroblasts and fibroblasts. The effect was not due to the polyanionic or polymeric nature of the molecule and appeared to be highly specific for HA.
将15日龄鸡胚成纤维细胞和成软骨细胞在高分子量和低分子量外源性透明质酸（HA）存在的情况下进行培养。测定其生长范围以及放射性标记硫酸盐和脯氨酸的掺入情况。HA将细胞增殖降低至对照的约75%，而成软骨细胞和成纤维细胞经HA处理的培养物中放射性标记硫酸盐和脯氨酸的掺入量更高。该效应并非由于该分子的聚阴离子或聚合物性质，似乎对HA具有高度特异性。
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