Department of Biological Sciences and Center for Environmental Radiation Studies, Texas Tech University, Lubbock, Texas 79409-3131, USA.
Radiat Res. 2013 Jan;179(1):29-37. doi: 10.1667/RR3029.1. Epub 2012 Nov 26.
Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiation exposures in utero. Pregnant laboratory mice (BALB/c) were exposed to low-dose Chernobyl radiation [10-13 mSv per day for 10 days] during organogenesis. The progeny were born and weaned in an uncontaminated laboratory, then were exposed to an acute radiation dose (2.4 Sv). Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100-130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure.
已知急性辐射暴露会导致生物损伤，从而引发严重的健康影响。然而，暴露于低剂量电离辐射的影响及随后的健康影响尚不清楚。本研究旨在探讨宫内低剂量电离辐射暴露的影响。在器官发生期，将怀孕的实验小鼠（BALB/c）暴露于低剂量切尔诺贝利辐射[每天 10-13mSv，共 10 天]。后代在无污染的实验室中出生并断奶，然后接受急性辐射剂量（2.4Sv）。对我们的终点（产仔动态、DNA 损伤、骨髓干细胞功能、白细胞计数和基因表达）的分析表明，宫内暴露于低剂量（100-130mSv）电离辐射对后代没有不良影响。相反，DNA 损伤、白细胞水平和基因表达结果表明，宫内暴露产生了放射适应性反应，从而减轻了随后的急性辐射暴露的影响。
