Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, CO 80249, USA.
Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA.
Int J Mol Sci. 2018 Nov 23;19(12):3729. doi: 10.3390/ijms19123729.
Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.
氧化应激与许多陆地疾病过程的病理生理学有关,并与航天飞行后的发病率有关。此外,氧化应激长期以来一直被认为是不良生殖结果的一个原因。本综述的目的是总结宇宙辐射和微重力引起的氧化应激的发病机制,综述氧化应激与女性生殖结局的关系,并探讨航天飞行引起的氧化损伤可能对女性生殖和发育结局产生的作用。