Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile.
Immunobiology. 2013 May;218(5):790-7. doi: 10.1016/j.imbio.2012.09.005. Epub 2012 Oct 4.
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways leading to an inflammatory reaction as part of an effective defensive response, are thus triggered. RAGE, a receptor initially considered for advanced glycation end-products, is also known to be activated by several danger signals, thus functioning as a pattern-recognition receptor. As a new member of this family, attempts to unraveling its functioning show that RAGE activation not only results in innate immune response but also contributes to promote and shape the acquired immune reaction. As reported for other members of the family, RAGE presents many polymorphic variants and additional studies are needed to elucidate its significance in immune response and disease susceptibility. Here we describe recent advances unraveling RAGE functions, as well as its significance and challenges in immunobiology.
模式识别受体在进化中高度保守。它们识别危险信号，包括病原体和损伤相关的分子模式，也称为警报素。因此，会触发几条导致炎症反应的信号通路，作为有效防御反应的一部分。RAGE 最初被认为是晚期糖基化终产物的受体，也已知可被几种危险信号激活，从而作为模式识别受体发挥作用。作为这个家族的新成员，试图阐明其功能的尝试表明，RAGE 的激活不仅导致先天免疫反应，而且有助于促进和塑造获得性免疫反应。正如该家族的其他成员所报道的那样，RAGE 存在许多多态性变体，需要进一步研究来阐明其在免疫反应和疾病易感性中的意义。在这里，我们描述了最近在阐明 RAGE 功能方面的进展，以及它在免疫生物学中的意义和挑战。
