Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshan East Road, Huanggu District, Shenyang City 110032, Liaoning province, China.
Mol Biol Rep. 2013 Jan;40(1):573-8. doi: 10.1007/s11033-012-2094-x. Epub 2012 Nov 25.
Many studies have investigated the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and hemorrhagic stroke, but the impact of MTHFR C677T on hemorrhagic stroke is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the strength of the association between MTHFR C677T polymorphism and hemorrhagic stroke risk. We searched Pubmed, Emabse and Wangfang databases for studies investigating the association between MTHFR C677T polymorphism and hemorrhagic stroke risk. We estimated the pooled odds ratio (OR) with its 95 % confidence intervals (95 % CI) to assess this possible association. Meta-analysis of included studies suggested that TT genotype was obviously associated with increased risk of hemorrhagic stroke (OR (TT versus CC) = 1.84, 95 % CI 1.45-2.34; OR (TT versus CT) = 1.53, 95 % CI 1.23-1.90; OR (TT versus CT/CC) = 1.64, 95 % CI 1.24-2.00) compared with CC or CT genotypes of MTHFR C677T polymorphism. Subgroup analyses by ethnicity further identified the association above in both Asians and Caucasians. No evidence of publication bias was observed. Thus, meta-analyses of available data suggest an obvious association between MTHFR C677T polymorphism and hemorrhagic stroke risk, and TT genotype contributes to increased risk of hemorrhagic stroke.
许多研究已经调查了亚甲基四氢叶酸还原酶 (MTHFR) C677T 多态性与出血性卒中之间的关系，但由于这些研究之间存在明显的不一致，MTHFR C677T 对出血性卒中的影响尚不清楚。本研究旨在量化 MTHFR C677T 多态性与出血性卒中风险之间关联的强度。我们搜索了 Pubmed、Emabse 和万方数据库，以调查 MTHFR C677T 多态性与出血性卒中风险之间的关系。我们用其 95%置信区间 (95%CI) 来评估这种可能的关联。对纳入研究的荟萃分析表明，TT 基因型与出血性卒中风险明显相关 (TT 与 CC 相比的比值比 (OR) = 1.84，95%CI 1.45-2.34；TT 与 CT 相比的 OR = 1.53，95%CI 1.23-1.90；TT 与 CT/CC 相比的 OR = 1.64，95%CI 1.24-2.00)。按种族进行的亚组分析进一步确定了上述在亚洲人和白种人中的关联。未发现发表偏倚的证据。因此，对现有数据的荟萃分析表明，MTHFR C677T 多态性与出血性卒中风险之间存在明显关联，TT 基因型增加出血性卒中风险。
