Department of Clinical and Toxicological Analyses, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Mol Biol Rep. 2013 Mar;40(3):2253-61. doi: 10.1007/s11033-012-2288-2. Epub 2012 Nov 27.
Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis.
子痫前期 (PE) 是一种多因素的妊娠特有的综合征，是全球孕产妇死亡的主要原因之一。遗传性血栓形成倾向已被研究为 PE 发展的危险因素，目前已知 ABO 血型可能影响止血平衡，非 O 型血（A、B 或 AB）人群比 O 型血人群更容易形成血栓。我们对已发表的研究进行了系统的文献回顾，以调查 ABO 血型是否会影响 PE 的发生。通过对四个数据库进行敏感搜索，确定了 45 个独特的标题。检索到的论文由作者独立评估，并进行了严格的选择和数据提取过程。还评估了纳入研究的方法学质量。两项研究符合入选标准。作为我们系统综述的主要发现，根据两项原始研究，发现 AB 血型与 PE 的发生之间存在关联。考虑到 ABO 血型在止血过程和血栓形成中的作用，应对携带 AB 血型的孕妇给予特别关注，以预防该综合征并改善预后。
