细胞外基质异质性调控乳腺腺癌细胞浸润的三维形态。
Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.
机构信息
School of Mechanical Engineering, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 136-713, Korea.
出版信息
Adv Healthc Mater. 2013 Jun;2(6):790-4. doi: 10.1002/adhm.201200320. Epub 2012 Nov 26.
Abstract
Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.
摘要
在一种新颖而强大的微流控体外平台上，以定量方式分析了乳腺癌细胞对各种细胞外基质（ECM）的可塑性和相互作用。这成功地证明了癌细胞的转移潜力，以及它们与其他细胞相互作用并侵入异质 ECM 时有效进行 ECM 蛋白水解重塑和形态变化的策略。
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