Advanced Biomedical Engineering Research Unit, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Adv Healthc Mater. 2012 Sep;1(5):657-60. doi: 10.1002/adhm.201200103. Epub 2012 Jul 12.
The synthesis, characterization, and functional evaluation of new size-controlled and biocompatible Gd(2) O(3) nanoparticles as a bimodal contrast agent for use in photoacoustic (PA) and magnetic resonance (MR) imaging are reported. These nanoparticles show a clear PA image by themselves, without conjugation with gold, rare earth metals, or dyes. Relaxivity measurement by MR imaging clearly shows that their relaxivity, r(1) , is twice that of clinically available Gd-DTPA.
报告了新型尺寸可控且生物相容的 Gd(2)O(3)纳米粒子的合成、表征和功能评估，该纳米粒子可用作光声（PA）和磁共振（MR）成像的双模态对比剂。这些纳米粒子本身就可以显示出清晰的 PA 图像，无需与金、稀土金属或染料结合。通过磁共振成像进行弛豫率测量清楚地表明，它们的弛豫率 r(1)是临床可用的 Gd-DTPA 的两倍。
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